Priorities in Parkinson's disease research
Identifieur interne : 000160 ( France/Analysis ); précédent : 000159; suivant : 000161Priorities in Parkinson's disease research
Auteurs : Wassilios G. Meissner [France] ; Mark Frasier [États-Unis] ; Thomas Gasser [Allemagne] ; Christopher G. Goetz [États-Unis] ; Andres Lozano [Canada] ; Paola Piccini [Royaume-Uni] ; José A. Obeso [Espagne] ; Olivier Rascol [France] ; Anthony Schapira [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; David M. Weiner [États-Unis] ; François Tison [France] ; Erwan Bezard [France]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2011-05.
Abstract
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.>
Url:
DOI: 10.1038/nrd3430
Affiliations:
- Allemagne, Canada, Espagne, France, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Grand Londres, Midi-Pyrénées, Nouvelle-Aquitaine, Occitanie (région administrative), Ontario
- Bordeaux, Cambridge, Londres, Toronto, Toulouse
- University College de Londres, Université de Bordeaux, Université de Cambridge, Université de Toronto
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ISTEX:B18DB94A38D88A12D621F99E69D4EEFEBBE7059ELe document en format XML
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Meissner</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux</wicri:regionArea><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Michael J. Fox Foundation for Parkinson's Research, New York, New York 10004</wicri:regionArea><wicri:noRegion>New York 10004</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and DZNE — German Center for Neurodegenerative Diseases, D-72076 Tübingen</wicri:regionArea><wicri:noRegion>72076 Tübingen</wicri:noRegion><wicri:noRegion>D-72076 Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea><wicri:noRegion>Illinois 60612</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Andres" sort="Lozano, Andres" uniqKey="Lozano A" first="Andres" last="Lozano">Andres Lozano</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Neuroscience, Imperial College London, London, SW7 2AZ</wicri:regionArea><wicri:noRegion>SW7 2AZ</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clínica Universitaria and CIBERNED, University of Navarra, 31008 Pamplona</wicri:regionArea><wicri:noRegion>31008 Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC9302, University Hospital of Toulouse, 31000 Toulouse</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Schapira, Anthony" sort="Schapira, Anthony" uniqKey="Schapira A" first="Anthony" last="Schapira">Anthony Schapira</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Institute of Neurology, University College London, London NW3 2PF</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 0SZ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Weiner, David M" sort="Weiner, David M" uniqKey="Weiner D" first="David M." last="Weiner">David M. Weiner</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>EMD Serono, Rockland, Massachusetts 02370</wicri:regionArea><wicri:noRegion>Massachusetts 02370</wicri:noRegion></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux</wicri:regionArea><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux</wicri:regionArea><wicri:noRegion>CHU de Bordeaux</wicri:noRegion><wicri:noRegion>CHU de Bordeaux</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="377">377</biblScope><biblScope unit="page" to="393">393</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">B18DB94A38D88A12D621F99E69D4EEFEBBE7059E</idno><idno type="DOI">10.1038/nrd3430</idno><idno type="ArticleID">nrd3430</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Grand Londres</li><li>Midi-Pyrénées</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Ontario</li></region><settlement><li>Bordeaux</li><li>Cambridge</li><li>Londres</li><li>Toronto</li><li>Toulouse</li></settlement><orgName><li>University College de Londres</li><li>Université de Bordeaux</li><li>Université de Cambridge</li><li>Université de Toronto</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. 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Meissner</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name></country><country name="États-Unis"><noRegion><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name></noRegion><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><name sortKey="Weiner, David M" sort="Weiner, David M" uniqKey="Weiner D" first="David M." last="Weiner">David M. 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